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Phase 2 Study of Upadacitinib (RINVOQ®) Alone or as a Combination Therapy Meets Primary and Key Secondary Endpoints in Patients with Systemic Lupus Erythematosus

- At week 24, upadacitinib 30 mg given alone or as a combination therapy (ABBV-599 high dose [elsubrutinib 60 mg and upadacitinib 30 mg]) met the primary...
United States Joan Merrill Roopal Thakkar Upadacitinib Monotherapy Arthritis Clinical Immunology Research Program Centers For Disease

Health Canada Approves AbbVie's RINVOQ® (upadacitinib) for the Treatment of Adults with Active Non-Radiographic Axial Spondyloarthritis (nr-axSpA)

- Approval is based on results from the Phase 3 SELECT-AXIS 2 pivotal clinical trial in which RINVOQ delivered rapid and meaningful disease control, meeting the primary endpoint of ASAS40 response at... | May 9, 2023
Denis Choquette Tracey Ramsay Canadian Spondylitis Association Canadian Spondyloarthritis Association Health Canada Abbvie Corporation

Novartis Pharma AG: Novartis Phase III APPOINT-PNH trial shows investigational oral monotherapy iptacopan improves hemoglobin to near-normal levels, leading to transfusion independence in all treatment-naïve PNH patients

Data at EBMT show primary endpoint met - estimated* 92.2% of complement-inhibitor-naïve patients with paroxysmal nocturnal hemoglobinuria (PNH) achieving 2 g/dL or more hemoglobin-level increase from baseline
South Korea France General United States Satoshi Sugimoto Julie Masow Giuseppe Moscati

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AbbVie Highlights Robust Gastroenterology Portfolio with New Analyses and Data in Inflammatory Bowel Diseases at the 18th Congress of European Crohn's and Colitis Organisation (ECCO)

A total of 24 accepted abstracts, including six oral and digital oral presentations, reinforce AbbVies commitment to research that helps advance standards of...
United States Silvio Danese Ann Gastroenterol Gastroenterol Hepatol Abbvie Ltd Peuropean Society Of Gastrointestinal Endoscopy

Novartis Pharma AG: Novartis presents pivotal Phase III APPLY-PNH data at ASH demonstrating investigational oral monotherapy iptacopan superiority over anti-C5

Trial met both primary and most secondary endpoints, showing iptacopan provided transfusion-free hemoglobin-level increases in vast majority of adult paroxysmal nocturnal hemoglobinuria (PNH) patients
France General United States Richard Jarvis Isabella Zinck Michael Meo Satoshi Sugimoto

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