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Frontiers | Contribution of the Gut Microbiota to Intestinal Fibrosis in Crohn's Disease

In Crohnโ€™s disease (CD), intestinal fibrosis is a critical determinant of a patientโ€™s prognosis. Although inflammation may be a prerequisite for the initiation of intestinal fibrosis, research shows that the progression or continuation of intestinal fibrosis can occur independently of inflammation. Thus, once initiated, intestinal fibrosis may persist even if medical treatment controls inflammation. Clearly, an understanding of the pathophysiological mechanisms of intestinal fibrosis is requ...
United Kingdom Japan General Nat Genet Fabio Cominelli Van Immerseel Darfeuille Michauda Crohn

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