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F. Hoffmann-La Roche Ltd: New data show Roche's subcutaneously administered crovalimab achieved disease control and was well-tolerated in people with paroxysmal nocturnal haemoglobinuria (PNH)

The COMMODORE 2 study demonstrated that subcutaneous crovalimab every four weeks was non-inferior to intravenous eculizumab every two weeks, with comparable safety, in people new to C5 inhibitors1Monthly
United States Gerard Tobin Nathalie Altermatt Levi Garraway Sileia Urech Loren Kalm

New data show Roche's subcutaneously administered crovalimab achieved disease control and was well-tolerated in people with paroxysmal nocturnal haemoglobinuria (PNH)

The COMMODORE 2 study demonstrated that subcutaneous crovalimab every four weeks was non-inferior to intravenous eculizumab every two weeks, with comparable safety, in people new to C5... | June 9, 2023
United Kingdom United States Nathalie Altermatt Karsten Kleine Levi Garraway Loren Kalm

New Data Show Genentech's Subcutaneously Administered Crovalimab Achieved Disease Control and Was Well-Tolerated in People With Paroxysmal Nocturnal Hemoglobinuria (PNH)

- The COMMODORE 2 study demonstrated that subcutaneous crovalimab every four weeks was non-inferior to intravenous eculizumab every two weeks, with comparable safety, in people new to C5 inhibitors
South San Francisco United States Gina Truslow Levi Garraway Loren Kalm Adam Pryor

Liso-cel CAR-T 'new potential treatment option' for advanced chronic lymphocytic leukemia

CHICAGO — Lisocabtagene maraleucel significantly improved complete remission rates among adults with relapsed or refractory chronic lymphocytic leukemia, results from the pivotal phase 2 TRANSCEND CLL 004 trial showed.Investigators reported no disease progression or deaths among individuals who achieved a complete response (CR) to the chimeric antigen receptor T-cell therapy, according to a
United States Bydrew Amorosi Tanya Siddiqi Mindy Valcarcel Ascentage Pharma Bristol Myers Squibb Celgene
Source: healio.com

Checkpoint inhibitor rechallenge fails to improve outcomes in metastatic kidney cancer

CHICAGO — The addition of atezolizumab to cabozantinib failed to improve clinical outcomes for patients with metastatic renal cell carcinoma who experienced progression on or after immune checkpoint inhibitor therapy, study results showed.Subgroup analysis of the randomized phase 3 CONTACT-03 trial, presented at ASCO Annual Meeting, did not identify any subset of patients who may benefit
United States Tonik Choueiri Bymatthew Shinkle Mindy Valcarcel Lank Center Bristol Myers Squibb
Source: healio.com

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Patients with high-risk chronic lymphocytic leukemia may benefit from treatment with ibrutinib plus venetoclax

First-line ibrutinib (Imbruvica) plus venetoclax (Venclexta) led to high response and survival rates in patients with chronic lymphocytic leukemia (CLL) whether or not their cancer harbored high-risk genetic features typically associated with poor outcomes, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR).
United States Megan Craig John Allan American Association For Cancer Research Clinical Cancer Research American Association

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