Page 102 - Genes News Today

The effect of two drugs used for the treatment of attention-deficit/hyperactivity disorder.

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

An expression signature related to inflammation expressed in Hofbauer cells in the placenta, calculating polygenic risk scores to predict its expression.

In an Australian study published in EClinicalMedicine, researchers evaluated the impact of a combined genomic screening program for hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia in young adults. The program proved to be cost-effective, reducing healthcare costs and averting numerous health events, while emphasizing the need for further optimization and equitable access within public healthcare systems.

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

In a comprehensive multi-ancestry GWAS meta-analysis, researchers identified 451 risk variants for prostate cancer, including 187 new variants, demonstrating the utility of such studies across diverse populations. This analysis not only increased understanding of genetic risk factors but also differentiated between aggressive and non-aggressive prostate cancer types, underscoring the potential of genetic risk scoring in guiding screening and early detection strategies.

In studies that examine the depressed brain, researchers were able to identify specific genes, molecules, brain regions, and cognitive features that are associated with the disorder.

A surprising thing happened when researchers began exploring whether early-life stress compounds the effects of a childhood head injury on health and behavior later in life: In an animal study, stress changed the activation level of many more genes in the brain than were changed by a bump to the head.

Scientists at La Jolla Institute for Immunology (LJI) are investigating a talented type of T cell.

The gene SYNGAP1, the variants of which are top risk factors for Autism Spectrum Disorder (ASD), has previously unappreciated effects on the developing brain, according to a new study published in Nature Neuroscience.