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Micronutrient deficiencies linked to gut microbiome shifts and antibiotic resistance

University of B.C. researchers have uncovered startling connections between micronutrient deficiencies and the composition of gut microbiomes in early life that could help explain why resistance to antibiotics has been rising across the globe.
United Kingdom Paula Littlejohn Bc Children Hospital Research Institute University Of British Columbia Nature Microbiology Antibiotic Resistance

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New insights into how cells maintain their identity over generations

Every cell in the human body contains the same genetic instructions, encoded in its DNA. However, out of about 30,000 genes, each cell expresses only those genes that it needs to become a nerve cell, immune cell, or any of the other hundreds of cell types in the body.
Leonid Mirny Dino Osmanovi Massachusetts Institute Of Technology National Human Genome Research Institute National Institute Institute For Medical Engineering

Scientists uncover "genomic tug of war" that influences chemotherapy's effectiveness

Some patients with myelodysplastic syndromes, like acute myeloid leukemia, benefit from a chemotherapy drug called decitabine that stunts cancer growth. But many others are resistant to decatibine's effects or become resistant over time.
Fanju Meng Patrick Murphy Wilmot Cancer Institute University Of Rochester Medical Center Environmental Health Science Center Rochester Medical

New approach to CAR T cell therapy may extend treatment effectiveness

CAR T cell therapy, a powerful type of immunotherapy, has begun to revolutionize cancer treatment. Pioneered at Memorial Sloan Kettering Cancer Center (MSK), the therapy involves engineering a patient's T cells so they recognize and attack cancer cells.
Zeguo Zhao Michel Sadelain Nayan Jain Sloan Kettering Institute Memorial Sloan Kettering Cancer Center Epigenetics Research

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