Genetic Reference Panel News Today

Study could lay foundation for developing drugs that treat or prevent cocaine addiction, and provides contextual framework for future research.

Credit: Clemson University New research from the Clemson University Center for Human Genetics has identified specific cell clusters in the brain of the common fruit fly affected by acute cocaine exposure, potentially laying the groundwork for the development of drugs to treat or prevent addiction in humans. While cocaines neurological effects are well known, the underlying genetic sensitivity to the drugs effects is not. In human populations, susceptibility to the effects of cocaine varies due ...

 E-Mail IMAGE: Robert Anholt and Trudy Mackay in a lab holding a test tube containing Drosophila melanogaster, the common fruit fly. view more  Credit: Clemson University College of Science Researchers Trudy Mackay and Robert Anholt of the Clemson University Center for Human Genetics have joined forces with an international consortium intended to drive research that will shape regulation and policy on chemical safety without the use of animal testing. Mackay, an internationally renow...

w 1118. ( B) Heatmap of the expression of TSC genes averaged across 2 days of observation. The presence of the characteristic circadian patterns in the tissue is indicated with black rectangles around the heatmaps. The number at the left designates the number of detected TSC genes. ( C and D) Heatmap of cycling in two (C) and three tissues (D) gene expression averaged across 2 days of observation. Black rectangles indicate tissues in which genes were found to be cycling. For (B) to (D), lighte...