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University of Birmingham research highlights new surgical standards for ovarian cancer

The National Institute for Clinical Excellence (NICE) has published new guidelines for the best surgery for some women who have advanced ovarian cancer. Maximal cytoreductive surgery is a major operation that aims to remove all visible disease when t
United Kingdom Sudha Sundar Institutes Of Cancer Genomic Sciences Cancer Research United Kingdom National Institute For Clinical Excellence University Of Birmingham

Combination therapy shows preliminary antitumor activity in pediatric neuroblastoma

The combination of olaparib and the investigational ATR inhibitor ceralasertib induced antitumor responses in children and adolescents with DNA repair-deficient tumors, according to phase 1 results of the AcSé-ESMART trial.The data, presented at American Association for Cancer Research Annual Meeting, also showed ceralasertib (AZD6738, AstraZeneca) plus olaparib (Lynparza, AstraZeneca) — a
United States United Kingdom Susanne Gatz Oren Becher Mindy Valcarcel Timothy Yap
Source: healio.com

Molecular Analysis Needed to Guide Further Study of Olaparib Plus Ceralasertib in Pediatric Advanced Cancers

The combination of PARP and ATR inhibition with olaparib and ceralasertib was tolerable but showed limited efficacy in pediatric patients with advanced malignancies harboring DNA replication stress and DNA repair deficiencies, according to findings from arm N of the phase 1/2 AcSé-ESMART trial.
United Kingdom Susanne Gatz Genomic Sciences Of The University Birmingham Institute Of Cancer Genomic Sciences Bayesian Optimal

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Researchers Have Identified Two Previously Unknown Genes Linked to Schizophrenia

The largest study of its kind also demonstrated that the risk is shared across ethnicities. A multi-center study, led by the Icahn School of Medicine at Mount Sinai, has uncovered two previously unknown genes that are associated with schizophrenia. Furthermore, the study uncovered a third gene that
Dongjing Liu Dannielle Lebovitch Panos Roussos Pamela Sklar Kerry Ressler Amanda Dobbyn

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