In China, a country hosting over 1,700 of the world’s roughly 30,000 orchid species, the orchid industry has witnessed substantial growth fueled by ad..
In China, a country hosting over 1,700 of the world’s roughly 30,000 orchid species, the orchid industry has witnessed substantial growth fueled by advancemen
BEIJING, April 8 (Xinhua) The following is a summary of published science and technology news of China. ROCKET LAUNCH China successfully launched SQX-1 solid
HKBU-led research facilitates more efficient hybrid rice breeding with pioneering female sterility technique asiaresearchnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from asiaresearchnews.com Daily Mail and Mail on Sunday newspapers.
Rabies is a lethal zoonotic disease that is mainly caused by the rabies virus (RABV). Although effective vaccines have long existed, current vaccines take both time and cost to produce. Messenger RNA (mRNA) technology is an emergent vaccine platform that supports rapid vaccine development on a large scale. Here, an optimized mRNA vaccine construct (LVRNA001) expressing rabies virus glycoprotein (RABV-G) was developed in vitro and then evaluated in vivo for its immunogenicity and protective capacity in mice and dogs. LVRNA001 induced neutralizing antibody production and a strong Th1 cellular immune response in mice. In both mice and dogs, LVRNA001 provided protection against challenge with 50-fold lethal dose 50 (LD50) of RABV. With regards to protective efficiency, an extended dosing interval (14 days) induced greater antibody production than 3- or 7-day intervals in mice. Finally, post-exposure immunization against RABV was performed to evaluate the survival rates of dogs rec