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TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders

TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

France
Belgium
Belgian
Bioanalyzer-agilent
Novocyte-quanteon
Graphpad-software-inc
Jackson-laboratory
Tree-star-inc
Ghent-university
Abbott-laboratories
Spike-epitope
Spike-tetramer

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1–AMPK–ACC Pathway

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1–AMPK–ACC Pathway
nih.gov - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nih.gov Daily Mail and Mail on Sunday newspapers.

Tokyo
Japan
Jingmei
Guangdong
China
Yancheng
Jiangsu
United-states
Jinmei
Shanghai
Wuhan
Hubei

An mRNA-based rabies vaccine induces strong protective immune responses in mice and dogs | Virology Journal

Rabies is a lethal zoonotic disease that is mainly caused by the rabies virus (RABV). Although effective vaccines have long existed, current vaccines take both time and cost to produce. Messenger RNA (mRNA) technology is an emergent vaccine platform that supports rapid vaccine development on a large scale. Here, an optimized mRNA vaccine construct (LVRNA001) expressing rabies virus glycoprotein (RABV-G) was developed in vitro and then evaluated in vivo for its immunogenicity and protective capacity in mice and dogs. LVRNA001 induced neutralizing antibody production and a strong Th1 cellular immune response in mice. In both mice and dogs, LVRNA001 provided protection against challenge with 50-fold lethal dose 50 (LD50) of RABV. With regards to protective efficiency, an extended dosing interval (14 days) induced greater antibody production than 3- or 7-day intervals in mice. Finally, post-exposure immunization against RABV was performed to evaluate the survival rates of dogs rec

Germany
United-states
Ashland
California
China
Finland
San-diego
Heidelberg
Baden-wüberg
Changchun
Jilin
Guangdong

Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization | Parasites & Vectors

Inflammatory bowel disease (IBD) is a chronic idiopathic disease characterized by inflammation-related epithelial barrier damage in the intestinal tract. Helminth infection reduces autoimmune disease symptoms through regulation of inflammatory responses based on hygiene theory. However, the underlying mechanisms remain unclear. BALB/c mice were infected with microcysts of E. granulosus sensu stricto and drank water containing 3.5% dextran sodium sulfate (DSS) at the 100th day post-infection. After 7 days of drinking DSS, the mouse body weight change and disease activity index (DAI) were recorded every day, and colon length and histological score were evaluated after sacrifice. After injection with antigen B (AgB), inducible nitric oxide synthase (iNOS) and Fizz1 expression and F4/80+CD11c+ M1 and F4/80+CD206+ M2 in the peritoneal cells and colon tissues were analysed by qPCR and flow cytometry, respectively. Gut microbiota were profiled by 16S rRNA sequencing of the mouse faec

China
Germany
Beijing
Dalian
Liaoning
United-states
Xinjiang
Jiangxi
Shanghai
Tree-star-inc
Graphpad-software-inc

Gut and cutaneous microbiome featuring abundance

Revealing causal role of gut microbiota dysbiosis in psoriasis pathogenesis and investigating protective effect of healthy commensal bacteria against imiquimod

China
Beijing
Helsinki
Eteläuomen-läi
Finland
Minhang
Shanghai
United-states
Bacteroidetes-firmicutes
Tree-star-inc
Ethics-committee-of-minhang-hospital
Dna-eraser-takara-biotech-co