Haplotype Reference Consortium News Today

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3–5. Here, to identify early disease-driving events, we performed traditional and multiplexed pancreatic tissue imaging, so...

Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis Aaron Leong , Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft Affiliations Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Division of General Internal Medicine, Massachusetts General Hosp...

Research Article Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study) Maria Brandkvist , Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Writing – review & editing Affiliations Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, Faculty of Nursin...