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Pepinemab/Trastuzumab With Dendritic Cell Vaccine and Adoptive T-Cell Therapy Under Evaluation in HER2+ Breast Cancer

A treatment regimen consisting of pepinemab plus trastuzumab and a dendritic cell vaccine, followed by autologous CD4-positive T cells, is under investigation in a phase 1 trial in patients with metastatic HER2-positive breast cancer.
United States Heather Han Breast Oncology Moffitt Cancer Center Her2 Positive Breast Cancer Breast Cancer

Gedatolisib, Fulvestrant, and Palbociclib Triplet Under Investigation in HR+/HER2– Breast Cancer

The combination of gedatolisib and fulvestrant with or without palbociclib is under evaluation in the phase 3 VIKTORIA-1 trial for the treatment of patients with PIK3CA-mutated or wild-type hormone receptor–positive/HER2-negative breast cancer who have previously progressed on first-line therapy.
San Antonio United States Heather Han Breast Oncology Moffitt Cancer Center Antonio Breast Cancer Symposium

Dr Han on the Investigation of Gedatolisib in HR+/HER2– Metastatic Breast Cancer

Heather Han, MD, discusses prior research with gedatolisib that provided the rationale for the phase 3 VIKTORIA-1 trial (NCT05501886) in patients with hormone receptor (HR)–positive, HER2-negative metastatic breast cancer.
Heather Han Department Of Breast Oncology Moffitt Cancer Center Breast Oncology Viktoria 1 Trial Patients With Hormone Receptor Positive

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