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 E-Mail IMAGE: Excess lipids produced by liver failure signal an itching sensation directly to the skin cells, through a receptor called TRPV4 and a microRNA. view more  Credit: Wolfgang Liedtke, Duke University DURHAM, N.C. - A devastating itching of the skin driven by severe liver disease turns out to have a surprising cause. Its discovery points toward possible new therapies for itching, and shows that the outer layer of the skin is so much more than insulation. The finding, which ...