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Prior SARS-CoV-2 infection enhances and reshapes spike protein–specific memory induced by vaccination

Prior SARS-CoV-2 infection enhances and reshapes spike protein–specific memory induced by vaccination
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Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
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United statesFrance generalSan franciscoChan zuckerberg biohubFondation bettencourt schuellerAndreas puschnikMilteny biotecSalud carlosJohn pakMicrobeta triluxSuzanne sandmeyerYuna muyshondtHelenc suAlzheimer research foundationUs department of defenseMercatus center at george mason university

Study suggests BCG vaccination might confer immunity to SARS-CoV-2

In a recent study posted to the bioRxiv preprint server, the researchers investigated the impact of Bacillus Calmette-Guérin (BCG) vaccine-induced antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein.

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Investigating extensive SARS-CoV-2 neutralizing immunoglobulins from COVID-19 recovered subjects

A new study discovered immunoglobulins with powerful broad-acting neutralizing capacity against SARS-CoV-2 from SARS-CoV-2 convalescents.

Potent human broadlyIgg antibodies effective against omicronIgg absMiddle eastIga absCoronavirus disease covid 19Covid 19Ars cov 2Ngiotensin converting enzyme 2B cellN vitroErs covEvere acute respiratoryEvere acute respiratory syndrome

Cureus | SARS-CoV-2 Antibody Seroprevalence in Patients With Cancer on Systemic Antineoplastic Treatment in the First Wave of the COVID-19 Pandemic in Portugal

At the time of the first wave of the COVID-19 pandemic, patients with cancer were considered to be at high risk of serious illness and had a higher exposure risk since they needed frequent and nondeferrable hospital visits. Serological tests were not routinely used, and seroprevalence in this population was unknown. A single-center, cross-sectional study was developed to determine the seroprevalence of anti-SARS-CoV-2 antibodies (Abs) in patients with cancer undergoing systemic antineoplastic treatment. One hundred patients were consecutively recruited in a two-week period (6th-20th May 2020), and serum samples were tested for the presence of immunoglobulin M (IgM) and immunoglobulin G (IgG) Abs directed against both spike (S) and nucleocapsid (N) SARS-CoV-2 proteins in two distinct time points (at recruitment and 4-8 weeks later). IgG-positive results were subject to confirmation, in the same serum sample, using two distinct assays. At the time of the first study visit, no patient

United statesPortuguese health authorityPortuguese national health authorityHospital da luz lisboa ethics committeeEastern cooperative oncology groupLuz lisboa ethics committeeMedical oncology unitIgg absCov iggIgg abbott architectAbbott diagnosticsOncology unitLuz lisboaPerformance statusAbbott architectDay hospital