"PIK Your Poison: The Effects of Combining PI3K and CDK Inhibitors agai" by Jay R. Perry, Benjamin Genenger et al.
Cutaneous squamous cell carcinoma (cSCC) is a very common skin malignancy with poor prognosis for patients with locally advanced or metastatic cSCC (mcSCC). PI3K/AKT/mTOR and cell cycle signalling pathways are often dysregulated in mcSCC. A combination drug approach has been theorised to overcome the underwhelming clinical performance of targeted inhibitors as single agents. This study investigates the potential of targeted inhibition of the p110ฮฑโsubunit of PI3K with PIK-75 or BGT226 (P13Ki)...
Cdk1 2 5 9 Combination Therapy Cutaneous Squamous Cell Carcinoma Cyclin Dependent Kinase Hosphoinositid 3 Kinase Ik 75
Source: uow.edu.au