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Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia. Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. The team found that the compound, named C28, not only prevents or reverses the negative physiological effects on the action potential, but does

Jianmin cuiMira cohenXiaoqin zouEmily hendersonInstitute for data scienceSkandalaris centerOffice of technology managementInstitute of clinicalEntrepreneurial acceleration programWashington university office of technology managementTranslational sciencesUniversity of missouriResearch innovation in biotechnologyProceedings of the national academy sciencesDalton cardiovascular research centerWashington university in st