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1. This retrospective cohort study found a U-shaped relationship between mean SBP and 3-month functional outcome after acute ischemic stroke, with an optimal mean SBP of 135-150 mmHg Evidence Rating Level: 2 (Good) Elevated blood pressure (BP) is frequently observed in acute ischemic stroke (AIS), possibly as a compensatory mechanism to increase perfusion to ischemic brain
Efficacy and Safety of Esketamine for Supplemental Analgesia During Elective Cesarean Delivery 1. In women undergoing cesarean delivery under epidural anesthesia, the administration of esketamine produced transient sedation and clinically insignificant analgesia, with no significant effect on neonatal depression. Evidence Rating Level: 1 (Excellent) Epidural anesthesia is commonly used during cesarean delivery. However, some patients