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IMAGE: The dECM-MA derived from porcine skeletal muscles is combined with PVA fibrillation, which provides the topographical cues for proper cellular alignment when bioengineering rat muscles. view more
Credit: Sang Jin Lee
WASHINGTON, May 11, 2021 When trauma, illness, or injury causes significant muscle loss, reconstructive procedures for bioengineering functional skeletal muscles can fall short, resulting in permanent impairments.
Finding a synergy in the importance of biochemical signals and topographical cues, researchers from Wake Forest Institute for Regenerative Medicine, Sungkyunkwan University, and Chonnam National University developed an efficient technique for muscle regeneration and functional restoration in injured rats. They describe results from the technique in the journal