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Genetic traits of Black Death survivors linked to autoimmune diseases today

Scientists find people with ERAP2 variant survived 14th-century plague at much higher rates

Luis barreiroHendrik poinarMcmaster universityUniversity of chicago medical centerUniversity of chicagoPasteur instituteBlack deathChicago medical centerEast smithfield

Black Death Made Humans Evolve

Scientists have found evidence for genetic adaptation to bubonic plague. But this rapid evolution may have come at a great cost.

City ofUnited kingdomLuis barreiroJavier pizarro cerdBlack deathMiddle eastNorth africaTech scienceHuman evolutionImmune systemHuman health

Black death survivors had plague-resistant genes that may boost their descendants risk of autoimmune disease

The Black Death pushed certain protective genetic variants to become more common in survivors descendants, DNA from the Middle Ages reveals.

City ofUnited kingdomLuis barreiroDavid enardUniversity of chicagoUniversity of arizonaBlack deathEast smithfieldTranslational gastroenterologyLive science

Selection of Human Immune-Related Genes Was Driven by the Black Death

Bubonic plague, or the "Black Death" placed significantly selective pressure on humans, changing the frequency of certain immune-related genes and affecting our susceptibility to modern diseases.

City ofUnited kingdomLuis barreiroG brian goldingSharonn dewitteChristiane demeureInstitut pasteurMariai patinoAlison caldwellMatthias steinrJavier pizarro cerdaXiaoheng chengHendrik poinarRebecca redfernAnne dumaineDominique missiakas

Scientists reveal how Black Death may have influenced evolution of human genes

Variants linked to protection against the 14th century bubonic plague are also associated with an increased susceptibility to autoimmune diseases.

City ofUnited kingdomUniversity of chicagoUnited statesLuis barreiroHendrik poinarMcmaster universityUniversity of chicago medical centerMuseum of london archaeologyMatt clarke mcmaster universityBlack deathChicago medical centerEast angliaEast smithfieldChicago medical

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