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Lysosomes are degradation and signalling centres crucial for homeostasis, development and ageing1. To meet diverse cellular demands, lysosomes remodel their morphology and function through constant fusion and fission2,3. Little is known about the molecular basis of fission. Here we identify HPO-27, a conserved HEAT repeat protein, as a lysosome scission factor in Caenorhabditis elegans. Loss of HPO-27 impairs lysosome fission and leads to an excessive tubular network that ultimately collapses. H...

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PlayTogga has reviewed and ranked 10 online gambling sites - and gives its verdict on each one

UK players are certainly not short of online casino bonuses. But as enticing as these deals might seem, you have to dig a little bit deeper to…

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