Marek Bartosovic News Today

This novel technology helps researchers better understand the mechanisms involved in gene expression.

An ongoing effort to create detailed molecular atlases of individual cells in different tissues aims to better understand how diseases develop. Now, a team of researchers from Yale and Karolinska Institutet, has developed a technology that brings that goal one step closer.  

The methods, developed independently but at the same time, use Tn5 transposase to generate NGS libraries to map epigenetic features of chromatin.

The methods, developed independently but at the same time, use Tn5 transposase to generate NGS libraries to map epigenetic features of chromatin.

Oligodendroglia at a crossroad in multiple sclerosis: proceed to the Myelin State or overcome epigenetic mountains to achieve the Immune State

A new method, single-cell CUT&Tag, gives an unbiased view of complex tissues with high resolution by examining epigenetic information in single cells.

Date Time Technique allows mapping of epigenetic information in single cells at scale Decoding epigenomic information from individual cells from the mouse brain. Histones are attached to DNA as beads on a string, with different versions decorating the genome as “epigenetic stickers”, labelling which genes are turned on or off. The method single-cell CUT&Tag allows to examine tens of thousands of single cells at the same time to determine their histone profiles. Illustration by Amagoia Agirr...