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Machine Learning Blood Test Detects Cancers with Genome-Wide Mutations in Single Molecules of Cell-Free DNA

Novel blood testing technology being developed by researchers at the Johns Hopkins Kimmel Cancer Center that combines genome-wide sequencing of single molecules of DNA shed from tumors and machine learning may allow earlier detection of lung and othe
Daniel Bruhm Vilmos Adleff James White Valsamo Anagnostou Rob Scharpf Jamie Medina

Oncolytic viruses could be used to 'warm up' cold tumors and improve immunotherapy

Equipping cancer-infecting, or oncolytic, viruses with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy to shrink or completely clear aggressive tumors in mice, according to a new study in the Journal of Experimental Medicine led by University of Pittsburgh and UPMC researchers.
United States Lukasz Wieteska Tianhong Yao Lily Ramsey Mclane Watson Kristin Depeaux

GABA transfer between skin cells promotes melanoma initiation

The transfer of a neurotransmitter from one type of skin cell to another (melanocytes to keratinocytes) altered electrical activity and promoted melanoma initiation in preclinical models, according to results published in Cancer Discovery, a journal of the American Association for Cancer Research.
United States Richard White Megan Craig Leon Black Family Foundation Pershing Square Sohn Foundation American Cancer Society

Electrical signals between skin cells may inf

The transfer of a neurotransmitter from one type of skin cell to another (melanocytes to keratinocytes) altered electrical activity and promoted melanoma initiation in preclinical models, according to results published in Cancer Discovery, a journal of the American Association for Cancer Research.
United States Richard White Ludwig Cancer Research National Institutes Of Health Pershing Square Sohn Foundation Starr Cancer Consortium

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Spanish researchers develop new immunotherapy combination for liver cancer

Spanish researchers at Cima University of Navarra have developed a new immunotherapy combination that improves efficacy in animal models of hepatocellular carcinoma. This is a proof of concept that lays the foundations for the application of this treatment in patients with the most common liver cancer.
New York United States Lily Ramsey Carmen Ochoa Ignacio Melero Saray Garasa

Study uncovers role of ultraviolet radiation

A change of scenery can restore one's outlook, but for some precancerous cells, a journey from the caves of the bone marrow to the sunny climes of the skin can trigger genetic changes that are a harbinger of cancer, according to a new study by researchers at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and the Broad Institute of MIT and Harvard.
United States Dana Farber Cancer Institute Katsuhiro Togami Daniel Ssozi Juliettem Bouyssou Volker Hovestadt

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