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Oncolytic viruses could be used to 'warm up' cold tumors and improve immunotherapy

Equipping cancer-infecting, or oncolytic, viruses with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy to shrink or completely clear aggressive tumors in mice, according to a new study in the Journal of Experimental Medicine led by University of Pittsburgh and UPMC researchers.
United States Lukasz Wieteska Tianhong Yao Lily Ramsey Mclane Watson Kristin Depeaux

Cancer Tricks Immune Cells, Immunotherapy Can Take Advantage

Cancer Tricks Immune Cells, Immunotherapy Can Take Advantage A paper published today in Nature shows how chemicals in the areas surrounding tumors—known as the tumor microenvironment—subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy. The study was conducted by a team of scientists at the University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, led by Pitt associate professor of im...
Mclane Watson Abigail Overacre Delgoffe Jeffrey Rothstein Brett Morrison Natalie Rittenhouse Stephanie Grebinoski

Insight about tumor microenvironment could boost cancer immunotherapy

 E-Mail IMAGE: Cancer evades the immune system by "feeding " the T cells that protect the tumor and "starving " the T cells that would attack. view more  Credit: UPMC, created with BioRender.com PITTSBURGH, Feb. 15, 2021 - A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy....
United States Mclane Watson Abigail Overacre Delgoffe Jeffrey Rothstein Brett Morrison Natalie Rittenhouse

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