Mark Leiser News Today

Sinusoidal obstructive syndrome is a rare but potentially serious complication that can occur after hematopoietic stem cell transplantation.On average, incidence of sinusoidal obstructive syndrome (SOS) among adults is 10%. In severe cases, the mortality rate can be as high as 80%.

May is Brain Tumor Awareness Month.An estimated 25,400 new cases of malignant brain or spinal cord tumors will be diagnosed in the United States this year, according to American Cancer Society, and approximately 18,760 people will die of the disease.

Blogs | | For years now, transplant physicians have spoken different languages when referring to a matter of utmost relevance — graft-versus-host disease.Here is a practical example: If a patient with lower gastrointestinal acute GVHD with a volume of stools of 900 ml per day with bloody stools — without another explanatory cause — is scored according to the original Glucksberg criteria,

CHICAGO — Adjuvant pembrolizumab showed durable benefit vs. placebo among patients with resected stage IIB or IIC melanoma, according to randomized phase 3 study results presented at ASCO Annual Meeting.After more than 3 years of follow-up, patients assigned the anti-PD-1 therapy achieved significantly longer distant metastasis-free survival (DMFS) and RFS, results of the KEYNOTE-716 trial

The addition of durvalumab to chemotherapy — either alone or in combination with olaparib — improved outcomes for women with advanced endometrial cancer, according to the agent’s manufacturer.Chemotherapy is standard first-line treatment for women with advanced endometrial cancer; however, long-term outcomes remain poor and more effective treatment options are needed.

Blogs | | A treosulfan-based reduced-toxicity conditioning regimen has significantly improved hematopoietic cell transplantation outcomes for patients with high-risk thalassemia major and hematologic malignancies.However, complications related to regimen-related toxicities, mixed chimerism and graft rejection limit its success.

Treatment intensification with darolutamide plus androgen deprivation therapy and docetaxel improved OS among men with metastatic hormone-sensitive prostate cancer regardless of disease volume or risk, according to study results.The benefits of early treatment intensification appeared consistent among men with high-volume or low-volume disease, as well as those with high-risk or low-risk disease,

Perichemotherapy antibiotics appeared associated with longer survival among patients with metastatic pancreatic ductal adenocarcinoma treated with gemcitabine, according to retrospective study results.Researchers did not observe the same benefit among patients treated with fluorouracil.

An oncology financial navigation intervention decreased financial toxicity among patients with blood cancers and their caregivers, according to study results.The intervention — called Coverage and Cost-of-Care Links (CC Links) — also received high ratings for acceptability and appropriateness, findings showed.

A high percentage of people with cancer exhibit what are known as SPPADE symptoms, according to study results.Investigators interviewed 31,886 people with cancer and assessed them for these symptoms, which include sleep disturbance, pain, physical function impairment, anxiety, depression, and low energy or fatigue.