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The University of Texas MD Anderson Cancer Center names vice president for research

Eyal Gottlieb, PhD, has been named vice president for research at The University of Texas MD Anderson Cancer Center. Gottlieb will oversee laboratory science departments that lead discovery and translational research across multiple disciplines. He will work closely with various MD Anderson staff to implement the university’s scientific research strategy.
United Kingdom United States Eyal Gottlieb Mark Leiser Rappaport Institute For Biomedical Research University Of Texas Md Anderson Cancer Center
Source: healio.com

Shared decision-making required when choosing first-line regimen for PD-L1-high NSCLC

CHICAGO — Chemoimmunotherapy and immunotherapy alone conferred comparable benefit as first-line therapy for most patients with advanced non-small cell lung cancer and high PD-L1 expression, results presented at ASCO Annual Meeting showed.Older patients appeared to derive better OS and PFS outcomes with immunotherapy alone, findings from the exploratory pooled analysis showed.
United States Sallyc Lau Oladimeji Akinboro Hossein Borghaei Mark Leiser
Source: healio.com

First-line brentuximab vedotin regimen extends OS in advanced classical Hodgkin lymphoma

CHICAGO — The addition of brentuximab vedotin to frontline chemotherapy significantly extended OS among patients with advanced classical Hodgkin lymphoma, according to study results presented at ASCO Annual Meeting.The experimental regimen conferred a 41% reduction in risk for death compared with standard chemotherapy, updated results of the randomized phase 3 ECHELON-1 trial showed.
United States Mayo Clinic In Rochester Catherine Sm Diefenbach Stephenm Ansell Mark Leiser Research To Practice
Source: healio.com

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Immunotherapy before head and neck cancer surgery does not increase complications

DALLAS — Neoadjuvant immunotherapy did not increase risk for complications among patients who underwent surgery for head and neck cancers, according to study results presented at American Head & Neck Society Annual Meeting.“Neoadjuvant immunotherapy is safe with the idea that definitive surgery will be performed within 4 to 8 weeks,” researcher Ramez Philips, MD, a
United States Ramez Philips Mark Leiser Thomas Jefferson University Hospitals Bristol Myers Squibb American Head Neck Society Annual Meeting
Source: healio.com

Defibrotide effective for veno-occlusive disease after HSCT

SALT LAKE CITY — Defibrotide benefitted adults and pediatric patients with severe or very severe veno-occlusive disease/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation, according to study results.The findings of the DEFIFrance study — presented at Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR — align with
United States Salt Lake City France General Defibrotide Defitelio Mohamad Mohty Mark Leiser
Source: healio.com

Recurrent ductal carcinoma in situ tumors often genetically distinct from primary lesion

A substantial portion of ductal carcinoma in situ recurrences did not appear genetically related to their primary lesions, according to study findings presented at American Association for Cancer Research Annual Meeting.De novo tumors with distinct genetic alterations accounted for nearly two in 10 recurrences, the detailed molecular analysis showed.
United States Tanjina Kader Larry Norton Mark Leiser American Association For Cancer Research Annual Meeting Victorian Cancer Agency
Source: healio.com

Enfortumab vedotin active in cisplatin-ineligible muscle-invasive bladder cancer

SAN FRANCISCO — Neoadjuvant treatment with enfortumab vedotin demonstrated promising activity among cisplatin-ineligible patients with muscle-invasive bladder cancer, according to study results presented at ASCO Genitourinary Cancers Symposium. More than one-third of patients achieved pathologic complete response and half achieved pathologic downstaging.
United States San Francisco Astellas Medivation Danielp Petrylak Eli Lilly Mark Leiser
Source: healio.com

Beta blocker use does not affect outcomes in immunotherapy-treated HCC

Use of beta blockers did not affect outcomes among patients treated with immunotherapy for unresectable hepatocellular carcinoma, according to study results presented at ASCO Gastrointestinal Cancers Symposium.Researchers reported comparable OS and overall response rates between those who used beta blockers and those who did not.
United States San Francisco Linda Wu Mark Leiser Cancers Symposium Mount Sinai Hospital
Source: healio.com

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