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Washington Research Foundation Awards Additional $1M to Fred Hutchinson Cancer Center Supporting Innovative Technology Commercialization Research in Life Sciences

Solid tumors use a type of T cell as a shield against immune attack

Fred Hutch scientists have identified a subset of immune-calming T cells that show up in great numbers in head and neck cancers, but not in similar tissues inflamed by gum diseases. This odd group of T cells have somehow been tricked into protecting these solid tumors from immune assault, but now might be precisely targeted by drugs to lift that protective shield.

Solid Tumors Use T Cells as a Shield Against Immune Attack

Researchers have discovered that solid tumors misuse a type of T cell, which protects them from the immune system.

Solid tumors use type of T cell as shield against immune attack

Solid tumors use type of T cell as shield against immune attack
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Sleuthing the immune system s mysterious T-regs

Fred Hutch immunologist Dr. Jennifer Lund knows that regulatory T cells, or T-regs, have an outsized and underappreciated role maintaining health and fighting disease. Her work shows how T-regs contribute to immunity to viral infections like COVID-19, HIV, West Nile Virus, Zika and herpes. In fact, it all started with herpes.

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