Pregnant female patients with rheumatoid arthritis (RA) treated with methotrexate and leflunomide within 3 months of conception faced an increased possibility of adverse pregnancy outcomes, specifically stillbirth or abortion.
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In this discussion with E. James Song, MD, several unique clinical pearls for those in dermatology were described and had been drawn from Song’s Winter Clinical presentation.
1. Methotrexate 20 mg once weekly resulted in significant pain reduction among patients with hand osteoarthritis of the inflammatory phenotype. 2. Adverse events in the treatment group were comparable to the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: Hand osteoarthritis is a debilitating condition with limited treatment options. Topical therapy, oral analgesics, and non-pharmacological therapy
1. Methotrexate 20 mg once weekly resulted in significant pain reduction among patients with hand osteoarthritis of the inflammatory phenotype. 2. Adverse events in the treatment group were comparable to the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: Hand osteoarthritis is a debilitating condition with limited treatment options. Topical therapy, oral analgesics, and
A network meta-analysis confirmed the efficacy of methotrexate for patients with rheumatoid arthritis (RA) and validated it as the primary reference conventional synthetic disease-modifying antirheumatic drug for treatment in this population.
A 20 mg weekly oral dose of methotrexate shows potential as a low-cost treatment for reducing pain and stiffness in patients with symptomatic hand osteoarthritis, according to the results of the METHODS trial.