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Immunosuppressed patients can benefit from COVID-19 booster vaccination, study shows

Patients under immunosuppressive therapy, who do not respond to primary COVID-19 vaccination, have an increased risk for severe COVID-19 disease courses. Until now, it was not clear whether those patients at risk can benefit from an additional booster vaccination.
Michael Bonelli Daniel Aletaha Emily Henderson World Health Organization Australian Technical Advisory Group On Immunization Meduni Vienna

Immunocompromised patients using rituximab could benefit from third COVID-19 booster vaccine

New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows immunocompromised patients using rituximab (a drug used to treat diseases like rheumatoid arthritis) were able to produce antibodies against COVID-19 (seroconvert) after receiving a third COVID-19 vaccine dose, even if there was no development of the antibody after the first two doses of the vaccine.
Michael Bonelli Emily Henderson Centers For Disease Division Of Rheumatology American College Of Rheumatology University Of Vienna

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Third Vaccine Dose May Protect Those With Autoimmune Diseases

As Michael Bonelli, senior author of the Vienna study, explains: โ€œB cells constitute an important cell population for the development of antibodies. We were able to show that more than 50% of patients receiving B-cell-depleting treatment with rituximab still develop antibodies to SARS-CoV-2 [Covid-19], and that there is potentially additional protection via a cellular immune response.โ€ This underscores the importance of vaccinating immunosuppressed patients against Covid, Bonelli said, whil...
United Kingdom Michael Bonelli Daniel Aletaha Cambridge University Committee On Vaccination Public Health England

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