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DNA sequencing of residual disease accurately identifies leukemia patients who would relapse

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.
University Of Pennsylvania United States City Of United Kingdom Jack Bartram Sara Ghorashian

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Sequencing of Bone Marrow DNA May Predict Leukemia Relapse After CAR-T Therapy With Sufficient Time to Intervene

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection accurately identified all patients who would eventually relapse, while other methods were less predictive, according to a study published in Blood Cancer Discovery, a journal of the American Association for Cancer Research.
University Of Pennsylvania United States City Of United Kingdom Miltenyi Biotec Jack Bartram
Source: utah.edu

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