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Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Researchers developed an intranasal trivalent measles-mumps-SARS-CoV-2 vaccine that provides robust protection against multiple coronavirus variants. Leveraging the established measles-mumps-rubella platform, this vaccine demonstrates broad and adaptable immune responses, especially against Delta and Omicron variants.
Ohio State University Institutional Laboratory Animal Care Severe Acute Respiratory Syndrome Coronavirus Measles Virus Mumps Virus Reverse Transcription Polymerase Chain Reaction Ohio State University

Antigenic cartography decodes the mysteries of SARS-CoV-2 variants and vaccines

Using antigenic cartography, researchers analyzed cross-reactivity patterns of SARS-CoV-2 variants and the effect of spike-protein changes on post-infection and vaccination immune responses. The study illuminated unique neutralization profiles and underscored the evolving defense mechanisms with repeated immunizations.
Drug Administration World Health Organization Institutional Review Board Coronavirus Efficacy Geometric Mean Titers Binding Domain

Novavax vaccine shows resilient defense against symptomatic COVID-19 despite Omicron challenge

Recent study assesses NVX-CoV2373 vaccine's effectiveness against Omicron variant. Findings show decreased efficacy over four months, but stable protection against symptomatic COVID-19.
National Integrated Surveillance System Estimated Effectiveness Primary Cycle Protein Recombinant Vaccine National Integrated Surveillance Coronavirus Disease Covid 19

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Differences in immune responses to SARS-CoV-2 variants could inform future vaccine design

A person's immune response to variants of SARS-CoV-2, the virus that causes COVID-19, depends on their previous exposure - and differences in the focus of immune responses will help scientists understand how to optimize vaccines in the future to provide broad protection.
United Kingdom Lily Ramsey Derek Smith Samuel Wilks University Of Cambridge Centre For Pathogen Evolution National Institutes Of Health

Protein recombinant vaccine NVX-CoV2373 confers protection during Omicron dominant period in Italy

The NVX-CoV2373 COVID-19 vaccine offers significant protection against symptomatic infections, but its effectiveness against SARS-CoV-2 declines within four months, according to a study in JAMA Network Open using Italian data. However, its protection against symptomatic COVID-19 seems to remain stable during this period.
Vidprevtyn Beta European Union European Medicines Agency National Integrated Surveillance Estimated Effectiveness Primary Cycle

Nirmatrelvir and ritonavir combo cuts COVID-19 risks for high-vulnerability groups

Nirmatrelvir and ritonavir treatment significantly reduces the risk of hospitalization and death from COVID-19 in high-risk individuals, according to a recent JAMA Network Open study. However, the treatment's efficacy varied based on the degree of vulnerability, emphasizing tailored approaches for different risk groups.
United States Kateryna Kon Shutterstock Drug Administration Ministry Of Health Hospitalization Among Patients With Vulnerability Image Credit

Why are most Americans skipping the COVID-19 booster?

A study in the journal Vaccine reveals that misinformation and concerns about side effects are leading reasons why over 80% of eligible Americans have skipped the SARS-CoV-2 vaccine booster. The research underscores the need for more public education about the vaccine's benefits in combating severe COVID-19 infections.
United States Drug Administration World Health Organization Disease Control Coronavirus Disease Covid 19 Medical Research

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