A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of dangerous irregular heartbeats.
Gene-Based Therapy Could Halt Deadly Heart Condition Progression miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
/PRNewswire/ A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular.
Gene-Based Therapy May Slow Development of Life-Threatening Heart Condition streetinsider.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from streetinsider.com Daily Mail and Mail on Sunday newspapers.
In a new study published in
Journal of Extracellular Vesicles, Chen-Yu Zhang s group and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output.
Over 100 years after insulin was discovered, it was believed that pancreatic β cells only secreted a single hormone insulin. Pancreatic β cell-derived insulin regulates glucose homeostasis by binding with the insulin receptors located in the liver, skeletal muscle, adipose tissues and other peripheral organs. The discovery of insulin and its receptor was essential to understand the mechanisms controlling glucose homeostasis and the pathogenesis of type 2 diabetes defined by defective insulin secretion, signal transduction and insulin resistance. However, glucose homeos