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BREAKING NEWS America s First 15-Minute City Has Been Created In Tempe, Arizona

A Tempe, Arizona, neighborhood has been named “Culdesac” and is America’s first example of a 15-minute city, a vision of the World Economic Forum and the globalist cult, who are pitching the concept as being more environmentally friendly. Instead of seeing this development as a dystopian nightmare, Culdesac residents appear to be thrilled at their new way of life, do they have any idea what they have in store for them?

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Optical-Plasmonic SERS Platform Clocks Molecular Systems | Research & Technology | Jan 2024

Optical-Plasmonic SERS Platform Clocks Molecular Systems | Research & Technology | Jan 2024
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Hong kongXin daiJinqing huangWenhao fuDollente mesiasHong kong university of scienceNature communicationsHong kong university

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang s group and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output. Over 100 years after insulin was discovered, it was believed that pancreatic β cells only secreted a single hormone insulin. Pancreatic β cell-derived insulin regulates glucose homeostasis by binding with the insulin receptors located in the liver, skeletal muscle, adipose tissues and other peripheral organs. The discovery of insulin and its receptor was essential to understand the mechanisms controlling glucose homeostasis and the pathogenesis of type 2 diabetes defined by defective insulin secretion, signal transduction and insulin resistance. However, glucose homeos

Jing liUnited kingdomXiang zhangJunfeng zhangAntonio vidal puigDameng liEunyoung leeShibei wangChen yu zhangXiaohong jiangYuchen liuXin daiMingliang zhangYujing zhangWeiping jiaCentury excellent talents in university

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang s group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver. Previously, Chen-Yu Zhang s group identified extracellular miRNA as a new form of cell-to-cell communication. They are among the first that reported the selective secretion of miRNAs under different physiological or pathological states; also, the uptake and function of secreted miRNAs in recipient cells. In the past decade, intensive studies have revealed the role of extracellular miRNAs in a range of biological processes. Thus, as a newly-emerged secretory factor, more insightful studies are needed to further reveal its relevance t

Jing liUnited kingdomXiang zhangJunfeng zhangAntonio vidal puigDameng liEunyoung leeShibei wangChen yu zhangXiaohong jiangYuchen liuXin daiMingliang zhangYujing zhangWeiping jiaCentury excellent talents in university