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Ibrutinib shows promise for children with chronic graft-versus-host disease

SALT LAKE CITY — Ibrutinib appeared safe and effective for children with previously untreated or relapsed/refractory chronic graft-versus-host disease, according to study results. Paul A. Carpenter, MD, professor at Fred Hutchinson Cancer Research Center, presented the results at Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR.
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Source: healio.com

FDA approves mavacamten, first treatment for obstructive hypertrophic cardiomyopathy

The FDA approved mavacamten for the treatment of symptomatic, obstructive hypertrophic cardiomyopathy, the first cardiac myosin inhibitor to be permitted for use in the United States, Bristol Myers Squibb announced.Mavacamten (Camzyos, Bristol Myers Squibb) is the first and only FDA-approved allosteric and reversible inhibitor selective for cardiac myosin that targets the underlying
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Source: healio.com

Erythematotelangiectatic, papulopustular rosacea most common of four major subtypes

Erythematotelangiectatic and papulopustular rosacea were found to be the chronic skin condition’s most common subtypes, according to a systematic review and meta-analysis. “Four distinct rosacea subtypes have traditionally been recognized, but the frequency of these subtypes among patients with rosacea remains unknown,” Yousef A. Barakji, MS, of the department of dermatology at
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Source: healio.com

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Unique food allergy conference aims to connect clinicians, families with experts

Families and clinicians alike often have questions about care when it comes to food allergies, from understanding cutting-edge treatments such as oral immunotherapy to addressing psychosocial burdens such as phobias and bullying. Answers and more can be found at the Food Allergy Conference for Education & Science (FACES) from June 10 to 11 in Chicago, according to its host, the Center for
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Source: healio.com

FDA grants orphan drug designation to off-the-shelf CAR-T for advanced multiple myeloma

The FDA granted orphan drug designation to ALLO-605, a chimeric antigen receptor T-cell therapy for adults with relapsed or refractory multiple myeloma.ALLO-605 (Allogene Therapeutics) is an allogeneic, gene-edited CAR T-cell therapy that targets the B-cell maturation antigen (BCMA) on the surface of cancer cells. The investigational agent was previously given fast track designation by the FDA.
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Source: healio.com

Factors predict survival after immunotherapy combination for HNSCC

DALLAS — Multiple factors predicted improved survival among patients with head and neck or salivary gland cancers treated with pembrolizumab plus vorinostat, according to prospective study results.Patients with lower pretreatment neutrophils and neutrophil-to-lymphocyte ratios — as well as those with more pretreatment lymphocytes and T helper cells — achieved longer OS and PFS,
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Source: healio.com

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