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The FDA proposed prohibiting menthol cigarettes and flavored cigars. The new product standards are designed to substantially prevent disease and death from combusted product use and to prevent young people from starting to smoke.“The proposed rules would help prevent children from becoming the next generation of smokers and help adult smokers quit,” HHS Secretary Xavier Becerra said

Tanezumab and NSAIDs both demonstrated early and sustained improvement in pain and function among patients with knee or hip osteoarthritis, according to data published in Arthritis Research and Therapy.

Ganaxolone was generally well tolerated and significantly reduced the frequency of seizures associated with CDKL5 deficiency disorder, according to a study published in The Lancet Neurology. “[CDKL5 deficiency disorder (CDD)] is a developmental and epileptic encephalopathy characterized by early-onset, refractory seizures and severe global developmental impairment,” Elia M. Pestana

DALLAS — Targeted sequencing appears to be a promising strategy for molecular profiling of head and neck squamous cell carcinoma, according to study results.The findings — presented at American Head & Neck Society Annual Meeting — showed a correlation between detection of circulating tumor DNA (ctDNA) and pathological adverse features.

The FDA granted breakthrough therapy designation to fam-trastuzumab deruxtecan-nxki for treatment of adults with unresectable or metastatic HER2-low breast cancer, according to a press release from the agent’s manufacturer.The designation applies to use of the HER2-directed antibody-drug conjugate by patients who previously received a systemic therapy in the metastatic setting or

The FDA has granted orphan drug designation to Gesynta Pharma’s GS-248, an oral small molecule, selective membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor, for systemic sclerosis, according to a company press release.

Oral calcium supplementation with or without vitamin D was associated with lower survival and a greater need for aortic valve replacement among older patients with mild to moderate aortic stenosis, researchers reported.In a large, retrospective analysis with extended follow-up, researchers also found that CV mortality was higher among older patients with mild to moderate aortic stenosis who were

WASHINGTON — A phase 2 study found that ST-100, a collagen mimetic peptide, could provide a new avenue for treatment of dry eye disease, according to a presenter at the American Society of Cataract and Refractive Surgery meeting.

Exposure to systemic corticosteroids appeared to increase risk for hospitalization for vaso-occlusive episodes among patients with sickle cell disease, according to a French study published in Blood.Those most likely to be hospitalized included older adults, women and patients not treated with hydroxyurea, researchers wrote.

The WHO has reported at least 169 cases of severe, acute hepatitis in children aged 1 month to 16 years from a dozen countries worldwide, according to a statement from the organization. According to WHO, one child has died and 17 children have received liver transplantation as a result of the disease. As of April 21, 114 cases have been reported in the United Kingdom, followed by Spain (13),