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CGM improves time in range, reduces HbA1c for older adults with type 1 diabetes

Older adults with type 1 diabetes initiating continuous glucose monitoring for the first time had a reduction in time spent in hypoglycemia, improved time in range and a lower HbA1c, according to findings from a randomized clinical trial. In the Wireless Innovation for Seniors with Diabetes Mellitus (WISDM) study, adults aged 60 years and older with type 1 diabetes randomly assigned to CGM had
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Source: healio.com

PPIs linked to risk for severe infection, decompensation in patients with cirrhosis

LONDON — Exposure to proton pump inhibitors correlated with an increased risk for severe infection and cirrhosis decompensation among a subset of patients with cirrhosis, according to research presented at the International Liver Congress. “The safety of PPIs in cirrhosis remains quite controversial,” Nadim Mahmud, MD, MS, MPH, MSCE, assistant professor of medicine and
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Source: healio.com

Joseph discusses AHA statement on managing CV risk in type 2 diabetes care

PHILADELPHIA — In this Healio video exclusive, Joshua J. Joseph, MD, MPH, FAHA, discussed the recent American Heart Association scientific statement on health equity in managing CV risk in type 2 diabetes.As Healio previously reported, the scientific statement, published in Circulation, is based on an extensive review of clinical trial results through June 2020 and addresses the managing of
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Source: healio.com

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Molecular signature-assisted drug selection may improve results in rheumatoid arthritis

Molecular signature response classifier-assisted rheumatoid arthritis treatment selection may improve real-world results in patients with rheumatoid arthritis, according to data published in Expert Opinion on Biological Therapy. “This study reports the second interim analysis of the [Accelerate Information of Molecular Signatures (AIMS)] real-world study evaluating the clinical utility of
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Source: healio.com

FDA grants fast track designation to PDS0101 for head and neck cancer subset

The FDA granted fast track designation to PDS0101 for treatment of certain patients with head and neck cancer.The designation applies to use of the agent in combination with pembrolizumab (Keytruda, Merck) by patients with recurrent or metastatic HPV16-positive disease.
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Source: healio.com

Health-related quality of life worse in NAFLD patients compared with general population

LONDON — Patients with nonalcoholic fatty liver disease had worse health-related quality of life, regardless of fibrosis stage, compared with the general population, according to research presented at the International Liver Congress. “Health-related quality of life has been shown to be impaired in NAFLD patients and potentially associated with fibrosis severity, obesity or other
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Source: healio.com

Gender-Equity Model for Liver Allocation more accurately predicts mortality vs. MELD

LONDON — The Gender-Equity Model for Liver Allocation and its sodium-corrected variant were better predictors of mortality or delisting in patients awaiting liver transplantation and may correct gender disparities, according to research. “The odds of delisting for sickness in women are 30% higher than in men, and this may have something to do with serum creatinine,” Manuel
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Source: healio.com

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