Mol Ther News Today

The Nobel Prize in Physiology or Medicine 2023 was awarded jointly to Katalin Karikó and Drew Weissman "for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19"

The 2023 Nobel Prize in Physiology or Medicine has been jointly awarded to Hungarian-American biochemist Katalin Kariko and American physician-scientist Drew Weissman, for work on messenger RNA (mRNA) technology that paved the way for groundbreaking

There are back door routes to the brain. COVID vaccine developers have traversed a path through those doors. ...

Gum made from a plant protein traps SARS-CoV-2, cutting the viral load in saliva, possibly curbing transmission, according to a study.

1 Abstract The devastating Ebola outbreak in West Africa in 2013-2016 accelerated the progress of several medical countermeasures (MCMs) against Ebola virus disease (EVD). Several IPs were used during that outbreak, but no conclusion on efficacy could be drawn. Only the Randomized Controlled Trial (RCT) on ZMapp was promising but inconclusive. More recently, during the second largest Ebola outbreak in North Kivu and Ituri provinces, Democratic Republic of the Congo (DRC), four IPs (Remdesivir, R...

Moving Forward after Two Deaths in a Gene Therapy Trial of Myotubular Myopathy 1 The sponsor of this clinical study, Audentes Therapeutics (which was acquired by Japan’s Astellas Pharma in 2019), had generated impressive efficacy studies in a canine model of MTM 2 and conducted non-primate (NHP) safety studies before advancing into the clinic. 3 The initial cohort of six pediatric MTM patients dosed at 1×10 14 genome copies (GC)/kg also showed encouraging results. However, all three patien...