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Analysis Helps Distinguish the Molecular Profile of Intraductal Carcinoma of the Prostate

Benjamin Miron, MD, explains the purpose of studying the molecular profile of intraductal carcinoma of the prostate, expands on the potential prognostic and targetable alterations identified in patients with this histology, and discusses the planned cohort expansion and analysis of RNA signatures in this population.
United States Fox Chase Cancer Center Benjamin Miron Caris Life Sciences World Health Organization Arasens Trial

U.S. launches new initiative testing tumor drug combinations

LOS ANGELES, June 1 (Xinhua) -- The U.S. National Cancer Institute (NCI) has launched a large precision medicine cancer initiative to test the effectiveness of treating adults and children with new drug combinations that target specific tumor alterations, the institute said on Thursday.
Jamesh Doroshow Division Of Cancer Treatment Us National Cancer Institute Cancer Institute Combination Therapy Platform Trial Molecular Analysis

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Molecular Analysis Needed to Guide Further Study of Olaparib Plus Ceralasertib in Pediatric Advanced Cancers

The combination of PARP and ATR inhibition with olaparib and ceralasertib was tolerable but showed limited efficacy in pediatric patients with advanced malignancies harboring DNA replication stress and DNA repair deficiencies, according to findings from arm N of the phase 1/2 AcSรฉ-ESMART trial.
United Kingdom Susanne Gatz Genomic Sciences Of The University Birmingham Institute Of Cancer Genomic Sciences Bayesian Optimal

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