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NSAIDs, hormonal contraception, and venous thromboembolism

A harmful drug interaction that deserves more attention Venous thromboembolism is a multifactorial disease, involving interactions between inherited and acquired risk factors such as immobilisation, active cancer, trauma or fracture, recent surgery, and—in young women—pregnancy and hormonal contraception.1 The magnitude of the risk from combined hormonal contraception depends on the dose of oestrogen and type of progestin.2 Although oestrogen causes hypercoagulability by promoting gene trans...
Morten Schmidt
Source: bmj.com

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NSAIDs and contraceptives: critical thinking on a harmful drug interaction

As an early career doctor I prescribed diclofenac liberally. It was my go-to anti-inflammatory drug for patients in hospital. My prescribing habit wasn’t influenced by evidence but by learnt behaviour. It was the drug others prescribed. Ibuprofen was one of the other options, and during my stint in rheumatology a consultant had warned me of people taking ibuprofen “like smarties” but being unaware of the risk of renal failure. If not ibuprofen, then diclofenac, or another non-steroidal ant...
Kamran Abbasi Morten Schmidt Alzheimer Association International Congress Association International Congress
Source: bmj.com

Women using NSAIDs alongside hormonal contraception may be at increased risk of blood clots

Women who use non-steroidal anti-inflammatory painkillers alongside hormonal contraception appear to be at a small increased risk of blood clots known as venous thromboembolism (VTE), finds a large Danish study published by The BMJ today.
Danielle Ellis Morten Schmidt At Aarhus University Hospital Morten Schmidt Aarhus University Hospital Anti Inflammatory Blood Clot

Use of common painkillers alongside hormonal

Women who use non-steroidal anti-inflammatory painkillers alongside hormonal contraception appear to be at a small increased risk of blood clots known as venous thromboembolism (VTE), finds a large Danish study published by The BMJ today.
Danish Heart Foundation Morten Schmidt At Aarhus University Hospital Method Of Research Novo Nordisk Danish Cancer Society Scientific Committee Morten Schmidt

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