Page 11 - Mouse Model News Today

Researchers have investigated the effectiveness of a bioengineered miniprotein in protecting against SARS-CoV-2 infection in vivo. The researchers evaluated the miniprotein, LCB1, against SARS-CoV-2-mediated lung disease in human ACE2-expressing transgenic mice.

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties.

Combination of deep brain stimulation and exercise has potential benefits for treating ataxia New research from Baylor College of Medicine scientists shows that a combination of deep brain stimulation (DBS) and exercise has potential benefits for treating ataxia, a rare genetic neurodegenerative disease characterized by progressive irreversible problems with movement. Working with a mouse model of the human condition, researchers at Baylor and the Jan and Dan Duncan Neurological Research Instit...

Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer’s Loss of smell or olfactory dysfunction is an early indication of the neurodegenerative Alzheimers disease (AD) and appears in approximately 90% of all patients. While loss of smell is a major symptom, patients with AD are only unable to recognize specific odors and do not completely lose their sense of smell; this suggests a possible region-specific involvement of the olfactive center in the ...

A promising strategy to improve functional capacity of damaged muscle Muscle is the largest organ that accounts for 40% of body mass and plays an essential role in maintaining our lives. Muscle tissue is notable for its unique ability for spontaneous regeneration. However, in serious injuries such as those sustained in car accidents or tumor resection which results in a volumetric muscle loss (VML), the muscles ability to recover is greatly diminished. Currently, VML treatments comprise surgica...

Low-frequency brain stimulation prevents seizures in mice with temporal lobe epilepsy Epileptic activity originating from one or more diseased brain regions in the temporal lobe is difficult to contain. Many patients with so-called temporal lobe epilepsy often do not respond to treatment with anti-epileptic drugs, and the affected brain areas must therefore be surgically removed. Unfortunately, this procedure only gives seizure freedom to about one third of patients, so the development of alter...

Study suggests a new way to personalize anti-CTLA-4 therapy for cancers A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. The tumors in question are relatively less reliant on burning sugar through a biochemical process known as glycolysis. Researchers led by Taha Merghoub and Jedd Wolchok of the Ludwig Center at Memorial Sloan Kettering C...

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the bodys glucose levels, which is important for the development of metabolic diseases like diabetes. In a recent study, published in The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical...

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.

Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma.