Page 12 - Mouse Model News Today

Researchers use cachexia model to assess cancer-derived myocardial impairments Oncotarget recently published "Evaluation of cancer-derived myocardial impairments using a mouse model" which reported that Myocardial damage in cancer patients is emphasized as a cause of death; however, there are not many murine cachexia models to evaluate cancer-derived heart disorder. Using the mouse cachexia model that they established previously, the authors investigated myocardial damage in tumor-bearing mice....

Study shows efficacy of radionuclide therapy–immunotherapy combination in prostate cancer model A combination of radionuclide therapy and immunotherapy has proven successful in slowing the progression of prostate cancer and increasing survival time, according to new research published in the February issue of The Journal of Nuclear Medicine. The results of the murine study indicate that radionuclide therapy promotes prostate cancer immunogenicity, provoking a cellular response that makes the...

Discovery of ‘Achilles heel’ in gut bacteria may lead to targeted therapies for Crohn’s disease The discovery of an "Achilles heel" in a type of gut bacteria that causes intestinal inflammation in patients with Crohns disease may lead to more targeted therapies for the difficult to treat disease, according to Weill Cornell Medicine and NewYork-Presbyterian investigators. In a study published Feb. 3 in Cell Host and Microbe, the investigators showed that patients with Crohns disease have ...

Muscle wasting, or the loss of muscle tissue, is a common problem for people with cancer, but the precise mechanisms have long eluded doctors and scientists. Now, a new study led by Penn State researchers gives new clues to how muscle wasting happens on a cellular level.

Remyelinating drug shows potential to improve vision in patients with MS A team led by a biomedical scientist at the University of California, Riverside, reports a drug -- an estrogen receptor ligand called indazole chloride (IndCl) -- has the potential to improve vision in patients with multiple sclerosis, or MS. The study, performed on mice induced with a model of MS and the first to investigate IndCls effect on the pathology and function of the complete afferent visual pathway, is published ...

Researchers identify new strategy to protect offspring from prenatal stress New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy. Working in a mouse model, Rachel Schroeder, a student in the UI Interdisciplinary Graduate Program in Neuroscience, drew a connection between the work of her two mentors, Hanna Stevens, MD,...

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity. Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system, in which nerve cells are attacked by the patients own immune system. In many ca...

The results of a study by researchers at the University of Texas Medical Branch may pave the way for a new medicine delivery system that could reduce the incidence of pre-term labor and premature birth by allowing physicians to treat the 'fetus as the patient'.

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans? The potentially deadly coronavirus disease 2019 (COVID-19) that has swept the world over the last 12 months has not affected animals with corresponding severity. In order to understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new prepr...

Study may help develop more effective personalized immunotherapy for cancer patients New research from CU Cancer Center member Jing Hong Wang, MD, PhD, and recent University of Colorado Immunology program graduate Rachel Woolaver, PhD, may help researchers develop more effective personalized immunotherapy for cancer patients. Working within Wangs specialty of cancer immunology and head and neck squamous cell carcinomas (HNSCCs), the researchers worked to establish a mouse model that would help ...