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Plumbing the 'dark' genome for new genes

Plumbing the ‘dark’ genome for new genes Updated: Updated: This can aid diagnosis, cure diseases Share Article AAA New revelaton: Mutations in the novel regions do have physiological consequences, says Sudhakaran Prabakaran.   | Photo Credit: Rasi Bhadramani This can aid diagnosis, cure diseases On June 26, 2000, former U.S. President, Bill Clinton, announced the completion of a draft sequence of the human genome, a historic landmark for genetic research. The Human Genome Project helped m...
United Kingdom Sudhakaran Prabakaran Bill Clinton University Of Cambridge Genome Research Laboratory Of Noncoding

SARS-CoV-2 evolves antibody resistance in immunocompromised patient

Researchers in the United States who tracked the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised patient found that convalescent plasma therapy was associated with the emergence of viral variants that were less susceptible to neutralizing antibodies.
United States United Kingdom Fort Detrick Steven Kemp Sally Robertson University Of Cambridge

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Scientists demonstrate how glue points and sequence alignment information can flag residue SARS-CoV-2 variants

Researchers in the U.S. have demonstrated how dominant energetic landscape mappings or glue points, along with sequence alignment information can potentially identify key residue mutations and spike protein deletions tied with emerging variants.
South Africa South African Protomer States Juan Gaertner Shutterstock Angela Betsaidab Laguipo University Of Minnesota

Defeating enemy within: How evolution helps clone fish with their genetic burden

Date Time Defeating enemy within: How evolution helps clone fish with their genetic burden According to scientific theories, clonal vertebrates actually have a harder time succeeding than species that reproduce sexually. Clonal fish and still successful: the Amazon molly. | Photo: Davied Bierbach One natural clone is the Amazon molly. A research team led by the Biozentrum of the University of Würzburg with the Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB) has shown that ov...
Wesleyc Warren Davied Bierbach David Bierbach Ronaldb Walter Jenny Ormanns Manfred Schartl

What's the difference between mutations, variants and strains? A guide to COVID terminology

Living through a global pandemic over the past year has seen all of us expanding our vocabularies. We now understand terms like PPE, social distancing and contact tracing. But just when perhaps we thought we had a handle on most of the terminology, we’re faced with another set of new words: mutation, variant and strain. So, what do they mean? The genetic material of SARS-CoV-2, the coronavirus that causes COVID-19, is called ribonucleic acid (RNA). To replicate, and therefore establish infec...
South Africa United Kingdom South African Oxford Astrazeneca Lara Herrero World Health Organisation

Substrain of SARS-CoV-2 variant in UK may resist antibody neutralization

Substrain of SARS-CoV-2 variant in UK may resist antibody neutralization Researchers at the Polish Academy of Sciences in Warsaw have identified a substrain of the recently emerged B.1.1.7 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may confer resistance to antibody neutralization. The SARS-CoV-2 virus is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that has now claimed the lives of more than 2.35 million people. The substrain of th...
South Africa United Kingdom South African Tomasz Lipniacki Sally Robertson Academy Of Sciences

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