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Study examines link between different epigenetic age measures and lung cancer risk

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 3, entitled, "Epigenetic age and lung cancer risk in the CLUE II prospective cohort study."

Brain cells may age faster in people with cocaine use disorder

A new study finds evidence from the DNA methylome that the biological age – different from the chronological age – of cells in Brodmann Area 9 of the prefrontal cortex might be greater in people with cocaine use disorder.

Cocaine use disorder leads to changes in the methylome of a brain region

Scientists tend to view substance addiction as primarily a disease of the brain. When we enjoy sex, food, music, or hobbies, regions of our brain within the reward pathway are flooded with pleasure-inducing dopamine.

Long-term caloric restriction has a small effect on the DNA methylation measure of the pace of aging

Researchers assessed the impact of caloric restriction on biological aging among the comprehensive assessment of the long-term effects of reducing the intake of energy (CALERIE) randomized controlled trial participants.

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow.

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