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New findings by UT Southwestern researchers help better understand the how one of the most commonly mutated genetic drivers of cancer passes signals

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.

Ion channel conserved in coronaviruses a potential new drug target for COVID therapeutics Much of the research on the coronavirus disease 2019 (COVID-19) therapeutics has been focused on essential structures such as the virus-encoded spike protein, main proteases, as well as ribonucleic acid (RNA) polymerase proteins. Obtaining high-resolution analyses of these structures provides a mechanical insight into their function and assists in using these structures as targets in the development of bot...

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer. It was precisely the discoveries of "key regulators of the cell cycle" and their implications for processes such as cancer, that won the British scientists R. Timothy Hunt and Paul M. Nurse and the American scientist Leland H...

Credit: CNIO Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer. It was precisely the discoveries of "key regulators of the cell cycle" and their implications for processes such as cancer, that won the British scientists R. Timothy Hunt and Paul M. Nurse and the American scientist Leland H. Hartwell the 2001 Nobel Prize in Physiology or Medicine. A study led by Ósc...

 E-Mail IMAGE: The background of the illustration is a photograph taken with the electron microscope showing DNA molecules decorated with MutS molecules, scanning the DNA for errors. The lower part shows... view more  Credit: CNIO Scientists from the Genomic Integrity and Structural Biology Group led by Rafael Fernández-Leiro at the Spanish National Cancer Research Centre (CNIO) have discovered how certain proteins ensure the repair of errors introduced into the DNA during its repli...

 E-Mail IMAGE: This model shows the structure of the spike protein in its closed configuration, in its original D614 form (left) and its mutant form (G614). In the mutant spike protein, the... view more  Credit: Bing Chen, PhD, Boston Childrens Hospital BOSTON - March 16, 2021 - The fast-spreading UK, South Africa, and Brazil coronavirus variants are raising both concerns and questions about whether COVID-19 vaccines will protect against them. New work led by Bing Chen, PhD, at Boston...

Posted on 7440 Wren Therapeutics Ltd., (“Wren”), a biopharmaceutical company pioneering a unique network kinetics approach to drug discovery for protein misfolding diseases, today announced the closing of a £12.4 million (c. $17.0 million) financing. This financing brings the total capital raised to date to approximately £33 million (c. $45 million). The financing was led by existing shareholder The Baupost Group, with particip...

Press release content from Business Wire. The AP news staff was not involved in its creation. Wren Therapeutics Announces Financing of £12.4 Million (c. $17.0 Million) January 25, 2021 GMT CAMBRIDGE, United Kingdom--(BUSINESS WIRE)--Jan 25, 2021-- Wren Therapeutics Ltd., (“Wren”), a biopharmaceutical company pioneering a unique network kinetics approach to drug discovery for protein misfolding diseases, today announced the closing of a £12.4 million (c. $17.0 million) financing. This fina...