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The Hidden World Of Protein Folding

The proteins upon which life depends share an attribute with paper airplanes: Unless folded properly, they just wont fly. But researchers have been puzzled by how the long, linear proteins cranked out by the ribosome factories in a cell are folded into the shapes they must assume to perform their function.
Baylor College Of Medicine United States San Francisco Judith Frydman Roadmap Initiative For Medical Research Massachusetts Institute Of Technology

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Researchers elucidate the mechanism behind the formation of pores in mitochondrial membrane

Mitochondria are considered to be the power plants of cells and are essential for human metabolism. Dysfunction in 40 percent of mitochondrial proteins are associated with human diseases, which is why mitochondria also play an important role in medical research.
Nils Wiedemann Nikolaus Pfanner Toshiya Endo Emily Henderson University Of Freiburg Kyoto Sangyo University

Folds in pUG molecules turn off genes and could provide clues about human disease

The RNA quadruple helix Roschdi and Butcher study, called a โ€œpUGโ€, can wind around itself four times to create a cube shape that can affect gene silencing. In this rendering, the uridine (U) nucleotides are blue while the guanosine (G) nucleotides are green.
Saeed Roschdi University Of Wisconsin Harvard University Department Of Biochemistry Nature Structural Molecular Biology

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