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Primary Result Of A Trial Must Be Reported Before Starting It. Here's Why!

Photo by Scott Graham on Unsplash Similarly, in clinical trials one starts with a target – aka primary endpoint. Generally this is the outcome of the trial you want to measure. These outcomes differ based on the kind of trial being planned. E.g. if we were planning a heart failure trial, some outcomes we might.. measure would be : improvement in LV function, improvement in symptom status, hospitalization, to just name a few. In Covid trials, these end points are determined based on the popula...
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Annie Duke's Great Lessons For Ambitious Founders

Very grateful to @AnnieDuke for her guest appearance on #StartingGreatness. She offers many great lessons for ambitious founders. Summarizing in the below thread… 1/ There are different types of “games” in business and in life. Some are based almost entirely on skill, like chess. Garry Kasparov will beat me 100 times in a row. Luck won’t rescue me. Some Games involve lots of chance and uncertainty. More like poker. 2/ If I play the world champion for an entire night, I likely lose my m...
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Leadership 101: Be A Practitioner, Not Just A Manager!

Leadership 101: Be a Practitioner, Not Just a Manager! I learned about leadership & scaling from Sheryl Sandberg. My direct manager for 10+ yrs, we spent countless hours together in weekly 1x1s (she attended religiously), meetings, offsites, dinners, travel, etc. Here are some of the most important lessons I took away from Sheryl: In one of our early M-team offsites, everyone shared their mission in life. Sheryl described her passion for scaling organizations. She was single-mindedly focused on...
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The "Three Attention Wars" Of Social Media!

If each war is winner-take-all and has one clearly superior format, then we’d expect the winner in each war to offer a feed that is 100% the best of that format. �� When Instagram launched and started delivering high-quality full-bleed pictures (incl. from many pro photographers!), FB’s legacy text-centric mixed-media feed was like a knife in a gun fight. IG quickly became the most engaging place on our phones. Until the 2nd war began. �� In the no-constraints heavyweight division, ...
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The Beer Biceps story: How the video content creator built a 7 Million+ strong Community on social media in 5 years

The Beer Biceps story: How the video content creator built a 7 Million+ strong Community on social media in 5 years (A thread) Therefore accumulate numbers and create your own niche. How to get numbers? – Entertain or Educate or Motivate – Create videos/pieces that address people’s most common questions/thoughts about the niche you’ve chosen. People will STICK with your social media handles when : – They see FRESH content (either the style or the information or the feeling of it) – ...
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Do you ever get called upon to give product feedback? Here's a guide to giving the correct feedback from the POV of a user for improving you product design

A guide below �� a) what problem this project is solving for users b) who the primary users are c) what success for the project is Get aligned on this before giving any feedback, otherwise you might speak past each other. Step 2: Put yourself in the shoes of someone who is the primary user, and go through the flow step-by-step. Wear your user hat right now, not your ‘company employee’ hat, and don’t just focus on key screens. Experience the actual end-to-end experience...
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