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"Zombie" viral fragments trigger inflammation to cause serious COVID-19 outcomes

There are many lingering mysteries from the COVID-19 pandemic. For instance, why does SARS-CoV-2, the virus behind the disease, cause severe symptoms in some patients, while many other coronaviruses don't? And what causes strange symptoms to persist even after the infection has been cleared from a person's system?
Victor Nizet Silvio Antoniak Hongkyu Lee Michael Yeaman Nigel Mackman Gerard Wong

Viral protein fragments may unlock mystery be

<ul> <li>There remains no clear explanation for why COVID-19, caused by SARS-CoV-2, can result in severe outcomes or death while other coronaviruses just cause common colds, or why COVID-19 symptoms persist after the coronavirus that causes it has been eliminated.</li> <li>A UCLA-led research team has shown that fragments of the coronavirus may drive inflammation by mimicking the action of specific immune molecules in the body.</li> <li>The findings could c...
Silvio Antoniak Nigel Mackman Hongkyu Lee Elizabeth Luo Victor Nizet Michael Yeaman

New therapeutic approach discovered for reducing the risk of thrombosis

 E-Mail IMAGE: First authors Taras Afonyushkin (left) and Georg Obermayer (right) with Last author Christoph Binder (middle) view more  Credit: Laura Alvarez/CeMM Thrombotic occlusion of blood vessels, which leads to myocardial infarctions, strokes and venous thromboembolisms, is the major cause of death in the western hemisphere. Therefore, it is of critical importance to understand mechanisms preventing thrombus formation. A new study by the research group of Christoph Binder, Princ...
United States San Diego Christoph Binder Georg Obermayer Bernd Jilma Waltraud Schrottmaier

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