New research finds connection: Inflammation, metabolism and scleroderma scarring
E-Mail Scleroderma, a chronic and currently incurable orphan disease where tissue injury causes potentially lethal skin and lung scarring, remains poorly understood. However, the defining characteristic of systemic sclerosis, the most serious form of scleroderma, is irreversible and progressive scarring that affects the skin and internal organs. Published in "We found that scleroderma inflammation dramatically increases CD38, an enzyme that normally breaks down a metabolic nutrient, NAD+. W...
United States Johann Gudjonsson John Varga Michigan Medicine Scleroderma Program Northwestern Scleroderma Program University Of Michigan
Source: eurekalert.org