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For older adults whose depression persisted while taking an antidepressant, adding aripiprazole had greater benefits than switching to another antidepressant.

1. In older adults with treatment-resistant depression, aripiprazole-augmentation significantly improved psychological outcomes compared to bupropion-augmentation or switching to bupropion. 2. In older adults with treatment-resistant depression, bupropion-augmentation was associated with a greater risk for falls than aripiprazole-augmentation. Evidence Rating Level: 1 (Excellent) Study Rundown: Major depressive disorder (MDD) is a common condition among older adults