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mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

In a study posted to the bioRxiv* preprint server, a team of researchers from the United States evaluated the protective effect of the preclinical version of the current Moderna Omicron-targeted mRNA-1273.529 vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 Omicron infection in mice.
United States Moderna Omicron Targeted Image Credit Coronavirus Disease Covid 19 Ouse Model Ngiotensin Converting Enzyme 2

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington's disease that recapitulates more Huntington's disease-like characteristics than earlier models.
Terry Semel X William Yang Xiaofeng Gu Emily Henderson Semel Institute Yang Lab

Unhealthy vaginal microbiome in mothers may contribute to infant deaths and altered development

A new study in mice from University of Maryland School of Medicine researchers showed that an unhealthy vaginal microbiome in pregnant mothers in combination with an unhealthy diet contributed to increased pup deaths and altered development in the surviving babies.
Akikok Bowers E Albert Reece Jacques Ravel Emily Henderson Nature Communications Epigenetic Research In Child Health Brain Development

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Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

A new study analyzed whether alveolar epithelial cell necrosis at an early stage SARS-CoV-2 infection and subsequent releases of damage-associated molecular patterns could aggravate COVID-19-associated acute respiratory distress syndrome.
Pansight Shutterstock Yokohama City University Hospital Early Alveolar Epithelial Cell Necrosis Potential Driver Image Credit Coronavirus Disease Covid 19

Study sheds light on how melanoma primes nearby lymph nodes for tumor metastases

Melanoma cells release small extracellular packages containing the protein nerve growth factor receptor, which primes nearby lymph nodes for tumor metastases, according to a new study by Weill Cornell Medicine investigators.
David Lyden Stavross Niarchos Emily Henderson Spanish National Cancer Research Center Metastasis Laboratory Ira Drukier Institute For Children Health

Newly developed gene therapy can treat a severe form of epilepsy and prolong survival

Research from the University of Virginia School of Medicine suggests how a newly developed gene therapy can treat Dravet syndrome, a severe form of epilepsy, and potentially prolong survival for people with the condition.
Ericr Wengert Manojk Patel Emily Henderson Augmentation Of Nuclear Gene Output Drug Administration University Of Virginia Health System

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