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Tyche is a machine-learning framework that can generate plausible answers when asked to identify potential disease in medical images. By capturing the ambiguity in images, the technique could prevent clinicians from missing crucial information that could inform diagnoses.
The death toll and monetary damages from landslides continue to rise despite advancements in predictive modeling. These models’ performances are limited as landslide databases used in developing them often miss crucial information, e.g., underlying movement types. This study introduces a method of discerning landslide movements, such as slides, flows, and falls, by analyzing landslides’ 3D shapes. By examining landslide topological properties, we discover distinct patterns in their morphology, indicating different movements including complex ones with multiple coupled movements. We achieve 80-94% accuracy by applying topological properties in identifying landslide movements across diverse geographical and climatic regions, including Italy, the US Pacific Northwest, Denmark, Turkey, and Wenchuan in China. Furthermore, we demonstrate a real-world application on undocumented datasets from Wenchuan. Our work introduces a paradigm for studying landslide shapes to understand thei
Most life scientists would agree that understanding how cellular processes work requires structural knowledge about the macromolecules involved. For example, deciphering the double-helical nature of DNA revealed essential aspects of how genetic information is stored, copied and repaired. Yet, being reductionist in nature, structural biology requires the purification of large amounts of macromolecules, often trimmed off larger functional units. The advent of cryogenic electron microscopy (cryo-EM) greatly facilitated the study of large, functional complexes and generally of samples that are hard to express, purify and/or crystallize. Nevertheless, cryo-EM still requires purification and thus visualization outside of the natural context in which macromolecules operate and coexist. Conversely, cell biologists have been imaging cells using a number of fast-evolving techniques that keep expanding their spatial and temporal reach, but always far from the resolution at which chemistr