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Molecule reduces inflammation in Alzheimer s models | MIT News | Massachusetts Institute of Technology

A new candidate drug reduced inflammation and improved memory in human cell cultures and Alzheimer’s mouse models. The work was co-led by the lab of Li-Huei Tsai at the Picower Institute for Learning and Memory.

Study connects neural gene expression differences to functional distinctions

The Picower Institute for Learning and Memory found that the two closely related neuronal subtypes differed from each other in how they expressed more than 800 genes. By manipulating genes whose expression differed most prominently, the scientists were then able to show how they produced several of the observable differences between the cells.

Sparse, small, but diverse neural connections help make perception reliable, efficient

MIT researchers report that thalamic inputs into superficial layers of the cortex are not only rare, but also surprisingly weak, and quite diverse in their distribution patterns. Despite this, they are reliable and efficient representatives of information in the aggregate, and their diversity is what underlies these advantages.

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